Isaiah 23:1. The burden of Tyre. Howl, ye ships of Tarshish: for it is laid waste, so that there is no house, no entering in: from the land of Chittim it is revealed to them.”
You can see that Tyre was on the coast of the Mediterranean Sea. Tarshish was all the across the Mediterranean, in what we now know as Spain. There was regular trade between the two cities, so when Tyre falls to Assyria, Tarshish and her merchant ships are going to lose a primary trading port.
The destruction of Tyre was terrible. No house was left standing. There was no one entering into the city. There was literally no available port there any more. Chittim refers to the Isle of Cyprus, and it could mean all of the islands in that end of the Mediterranean that were stops for trading ships. So great was the destruction that it affected trade in the islands as well as in Tyre itself.