Isaiah 13:6. “Howl ye: for the day of the Lord is at hand; it shall come as a destruction from the Almighty.”
If you will keep in mind that “the Day of the Lord” is a reference to the future, the Second Advent, it will help you to understand that these are far-future prophecies. Babylon is going to be rebuilt at some point. There are those who believe Saddam Hussein tried to get that project underway. Babylon is always representative of the rise of godlessness and evil, and in the Day of the Lord its destruction will be complete.
Those who mock at God and deny His existence will learn to their horror that He is indeed the only God, the Holy One of Israel. His judgments upon the world are sure, and those who have persecuted His people, Israel, are going to suffer for their pride and their hatred. God’s judgments will be upon the whole world (tebel, the whole earth).
Scriptures for comparison: Is. 34:1-8; Joel 2:31; 3:15; Matt. 24:29; Mark 13:24; Luke 21:35.