The sense of peace and safety will be quickly and completely destroyed. Sudden indicates that the doom which overtakes the world is unexpected and unforeseen, catching them totally unprepared. They are so confident that everything is finally and unchangeably perfect that the onset of destruction is a shock. Destruction has the sense of utter and hopeless ruin, the loss of all that gives worth to their very existence. It does not denote loss of being, but rather loss of well-being; it is the ruin of the very purpose of their existence. II Thess. 1:9-10 says: “Who shall be punished with everlasting destruction from the presence of the Lord, and from the glory of His power; when He shall come to be glorified in His saints, and to be admired in all them that believe (because our testimony among you was believed) in that day.”
Paul uses the word destruction here to indicate the eternal separation from Christ of the lost. It is the opposite of the salvation awaiting believers. And this destruction will come in a way compared to a woman going into labor; once it has started, there is no turning back, no time to say, “Wait, I’ve changed my mind, I don’t want to do this!” The time to decided not to have a baby is before that baby is conceived. Once the pregnancy comes to term, the only deliverance is to go through the labor and the birth. There is no escape once those pains have begun, and there is no escape for those who have denied the truth of God’s Word once He sets His plan for the end times into motion.
Knowing that people will have no more opportunity to accept Christ should motivate us to take/make every opportunity to offer Him to those around us. The words no escape are final. Death is final. The separation from God forever for those who do not believe is final. No escape.